Hackers break into the Tesla car web browser to win a Model 3 – TechRadar

Tesla Model 3

Image credit: Tesla

Well it’s certainly one way to get yourself a Model 3: hackers have successfully exploited a security hole in Tesla’s in-car browser at the Pwn2Own hacking contest, earning themselves one of the electric cars as a prize.

TechCrunch reports that Richard Zhu and Amat Cam – aka team Fluoroacetate – were able to bypass various security measures to get a message displayed on the browser.

Tesla has said it will issue a fix for the bug to prevent it being exploited in the future. Meanwhile, the Fluoroacetate team walked away from Pwn2Own with some $375,000 (about £283,700 or AU$529,100) in prize money, as well as their new car.

“We understand that this demonstration took an extraordinary amount of effort and skill, and we thank these researchers for their work to help us continue to ensure our cars are the most secure on the road today,” said Tesla in a statement.

Browser changes

It’s worth pointing out that the bug that Zhu and Cam exploited was limited to the browser – they weren’t able to take control of the car or anything like that.

At the same hacking conference, hundreds of thousands of dollars were paid out for bugs discovered in Apple Safari, Microsoft Edge, Microsoft Windows, VMware Workstation and Mozilla Firefox.

In other Tesla browser-related news, CEO Elon Musk announced on Twitter that the in-car software would soon be making the switch to Chromium – the same open source code that Google Chrome is built on.

Whether or not that makes the browser more secure remains to be seen, but as always, don’t try browsing the web and driving a car at the same time.

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Failed Alzheimer’s trial leaves families and patients heartbroken. Medical community reels – CNBC

Jeff Borghoff, 54, was enrolled in a clinical trial for aducanumab, a drug aimed at slowing the progression of Alzheimer's disease. The drug's developers, Biogen and Eisai, announced in March they were ending the trial. From left to right: Michael, Jeff, Erin (in front of Jeff), Kim and Aubreigh.

Courtesy of The Borghoff Family.

Jeff Borghoff, 54, was enrolled in a clinical trial for aducanumab, a drug aimed at slowing the progression of Alzheimer’s disease. The drug’s developers, Biogen and Eisai, announced in March they were ending the trial. From left to right: Michael, Jeff, Erin (in front of Jeff), Kim and Aubreigh.

Every month, a car would pick up Jeff Borghoff at his home in Forked River, New Jersey, and drive him to the Advanced Memory Research Institute of New Jersey. There, doctors would help him settle into a comfortable chair and hook him up to an IV.

“I just knew right away. It was a gut feeling, sixth sense kinda thing,” said Borghoff, 54, who was diagnosed with Alzheimer’s at 51.

The bad news was the companies developing aducanumab, Biogen and its partner Eisai, announced earlier that day that they halted two late-stage trials of the experimental drug after an independent group’s analysis showed that the trials were unlikely to “meet their primary endpoint.”

The Cambridge, Massachusetts-based biotech giant joins a long list of companies in the last decade that have failed to find a treatment for Alzheimer’s, a progressive and debilitating disease that often affects a person’s memory, thinking and behavior.

Billions lost

Biogen and Eisai lost billions of dollars in market value. The scientific community viewed the announcement as a setback after spending billions to research and develop possible treatments — with almost nothing to show for it. Patients and families living with the disease who had pinned their hopes on aducanumab were heartbroken.

This failure is just the latest in a string of experimental treatments targeting a protein-fragment in the brain known as beta amyloid. Many scientists and drugmakers think it plays a prominent role in the devastating disease by eroding synapses between nerve cells. Some trials are already underway to test other ways of attacking Alzheimer’s.

Salim Syed, senior biotech analyst at Mizuho Securities who covers the stock, said Biogen’s failure was a shock to many as the Alzheimer’s treatment showed promise and followed the widely accepted theory that beta amyloid was responsible for the disease.

Drawing board

“The challenge now is we’re back to the drawing board when it comes to Alzheimer’s,” Syed contended.

Alzheimer’s disease can cause people’s memory and mind to deteriorate to the point where they cannot function on their own and eventually die. It’s the sixth leading cause of death in the U.S., and the Alzheimer’s Association estimates 5.8 million Americans are living with the disease.

More than 16 million Americans care for someone with Alzheimer’s disease without pay, an experience that can be intensive and emotionally taxing. This year alone, Alzheimer’s and other dementias will cost the U.S. $290 billion, according to the Alzheimer’s Associations.

Amyloid plaques accumulate outside neurons. Amyloid plaques are characteristic features of Alzheimer's disease. They lead to a degeneration of the affected neurons.

Getty Images

Amyloid plaques accumulate outside neurons. Amyloid plaques are characteristic features of Alzheimer’s disease. They lead to a degeneration of the affected neurons.

Despite the disease being common and its effects and challenges being well-documented, scientists don’t know much about it. They don’t know what causes Alzheimer’s nor do they understand how exactly the disease works, making it challenging to find ways to treat or cure it.

Alleviating symptoms

The FDA has approved four Alzheimer’s drugs, all of which are aimed at helping symptoms, not actually reversing or slowing the disease itself. That’s not to say people aren’t trying. The National Institutes of Health alone expects to invest $1.46 billion on Alzheimer’s research this year, almost three times the $562 million spent in 2014.

“Our brain is a complex organ and this is a complex disease,” said Heather Snyder, senior director of medical and scientific operations for the Alzheimer’s Association.

Kim Borghoff wanted her husband Jeff to screened for the disease after he started “zoning out” for no apparent reason, she said. His father, uncle and other relatives had Alzheimer’s and she wasn’t buying his diagnosis of epilepsy. She called Columbia University Medical Center every day, twice a day until she got an appointment, having already tried other hospitals.

‘Get your affairs in order’

They ran numerous tests. About 18 months after first trying to get a diagnosis, Kim finally had the answer. She was sitting at her desk when the doctor called.

“She said, ‘I’m sorry to tell you, Jeffrey has Alzheimer’s. All the tests came back and he’s early in the stages. Get your affairs in order,”‘ Kim recalls the doctor saying.

She drove home and on the way back called Jeff to tell him they were going to the park. She told him not to ask any questions or say anything to his mother, who was living with them and caring for her husband who had Alzheimer’s. They drove to the park and sat on a bench where she told him the news.

“He broke down. I broke down. Then he said i’m going to fight this and he’s been fighting this ever since,” she said. That was three years ago.

Try and fail

From 1998 to 2017 there have been about 146 unsuccessful attempts at developing drugs for Alzheimer’s disease, according to the Pharmaceutical Research and Manufacturers of America, or PhRMA, the industry’s main trade group. That means for every research project that succeeded to yield a new medicine, about 37 failed.

Major drug companies such as Pfizer, Johnson & Johnson, Eli Lilly and Merck have ended their attempts to treat Alzheimer’s by targeting beta amyloid after failing to produce good results. In January, Swiss drugmaker Roche announced that it was ending two-late stage trials for Alzheimer’s that also targeted beta amyloid. It’s still testing another amyloid drug at a higher dose.

Moving on

Dr. Richard Mohs, a former head of Eli Lilly’s Neuroscience Clinical program, said “as a field, we may need to move on and look at other scientific plausible ways to try and treat the disease” besides amyloid-targeting drugs.

“It’s been difficult,” said Mohs, who is working on another clinical trial focusing on tau, an Alzheimer’s protein that is believed to be closely linked with the onset of symptoms. The Biogen trial was “well designed and well executed.”

The exterior of the headquarters of biotechnology company Biogen in Cambridge, MA is pictured on March 21, 2019.

John Tlumacki | Boston Globe | Getty Images

The exterior of the headquarters of biotechnology company Biogen in Cambridge, MA is pictured on March 21, 2019.

Jeff Borghoff was gardening, his new hobby after he had to leave his job as an IT architect, one day when his new neighbor walked over. Jeff mentioned his Alzheimer’s diagnose and his neighbor said sure enough, his wife had just started working for the Advanced Memory Research Institute.

Once Jeff connected with the center, researchers determined he was eligible for the aducanumab trial. Jeff and Kim were “so excited,” she said. The first 18 months was a double-blind placebo study, meaning Jeff didn’t know whether he was getting the treatment or the placebo.

Then they revealed he was receiving the treatment. He and Kim felt like it had slowed the progression of the disease, though they have not seen any of the results. Jeff knew that since this was an experiment, the treatment could fail and the drugmaker could end the trial at any point.

Still, he and his family were not quite prepared for it to really end.

Pushing forward

Even though recent experimental treatments haven’t produced any new drugs, they still have helped researchers learn more about the brain and the disease, Snyder said. Scientists are starting to understand that a person’s brain starts to change about a decade or so before they’re diagnosed with Alzheimer’s disease.

“We are absolutely committed to making sure no stone is left unturned and that all avenues are pursued,” Snyder said. “We are optimistic that as our understanding of the science continues to grow and go forward, our ability to both target the different biologies but also combining some of those pieces together expands.”

The Borghoff’s called a family meeting Thursday night. Jeff, positive as always, said he wanted to find another clinical trial to enroll in so he could help scientists find a treatment or a cure that might help his kids or grandkids.

Kim wants him to try medical marijuana or CBD oil. She hopes these options might quell the anxiety and anger Jeff increasingly experiences. However, neither have been approved by the FDA to treat or manage Alzheimer’s or other dementias, nor have they been evaluated in clinical trials. It’s also unclear how people with dementia would respond to the psychoactive effects of marijuana or how it would interact with the other drugs used to treat the desease.

“I’m still looking at all of the possibilities and all of the angles. I’m of the philosophy that a box has six sides and I can only see three sides at a time,” Jeff Borghoff said. “There are other perspectives to look at and other things to take into consideration.”

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Dow falls 400 points as recession indicator flashes red – CNN

New York (CNN Business)The Dow fell 400 points Friday as a leading recession indicator stoked fear among investors.

The yield on 3-month Treasuries rose above the rate on 10-year Treasuries for the first time since 2007 — a shift that spooked Wall Street and sent the Dow plunging. Investors have piled back into stocks after a sell-off in late 2018.
The flattening yield curve, or the difference between short- and long-term rates, has worried investors for months. A narrowing spread is typically seen as sign that long-term confidence in the economy is waning, which could signal an eventual economic contraction.
Friday’s flip added to an already rough start for the Dow, which is now down about 1.5%.
The index stumbled at the opening bell on poor manufacturing data from Germany, which also spelled trouble for the country’s bond market. The yield on Germany’s benchmark 10-year government bond fell below zero for the first time since October 2016.
All of that news is fueling Wall Street’s ongoing concerns about slowing global growth.
White House economic adviser Larry Kudlow told CNBC last year that the spread between 3-month and 10-year Treasury yields was important to watch.
“It’s actually not 10s to 2s; it’s 10s to 3-month Treasury bills,” Kudlow said last May. He was referring to the spread between 2-month and 10-year Treasury yields, which is also closely monitored.
The Dow wasn’t the only major US index to see losses Friday. The S&P 500 dropped more than 1.5% by midday. The Nasdaq was also down roughly 2%.
Michael Darda, chief economist and market strategist at MKM Partners, said in a note that investors should wait for weekly and monthly averages to show an inversion before they read it as a “powerful recession signal.”
And he noted that on average, recessions occur 12 months after an inversion — not immediately.

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